Peripheral arterial disease is one of the most common diseases in societies that have put a heavy burden on the health systems. Studies on various surgical procedures in patients with the peripheral arterial disease have examined the limited number of patients with involvement in different vascular segments of the lower extremities and compared their therapeutic outcomes with different treatment methods. However, in Iran, such studies are performed at a very limited level, so that their results cannot be used for treatment planning, as well as the comparison of different surgical methods. We examined 300 patients who underwent Femoropopliteal bypass surgery with autogenous saphenous vein, from 2009 to 2019 in Shohadaye Tajrish hospital (Tehran, Iran). We recorded, reported, and analyzed information obtained from histories record and patient follow-up. Femoropopliteal bypass surgery using an autogenous saphenous vein in the treatment of peripheral vascular disease according to common criteria such as ten-year mortality, intraoperative mortality, primary patency, gangrene, and postoperative amputation, as well as postoperative complications, compared to other alternative operations had been successful. Femoropopliteal bypass surgery with an autogenous saphenous vein is very promising and recommended.